The utilization of positron emission tomography in the evaluation of renal health and disease

Abstract Purpose Positron emission tomography (PET) is a nuclear imaging technique that uses radiotracers to visualize metabolic processes of interest across different organs, diagnose and manage diseases, monitor therapeutic response. This systematic review aimed characterize the value PET for assessment renal metabolism function in subjects with non-oncological disorders. Methods was conducted reported accordance PRISMA statement. Research articles reporting “kidney” or “renal” evaluated between 1980 2021 were systematically searched Medline/PubMed, Science Direct, Cochrane Library. Search results exported stored RefWorks, duplicates removed, eligible studies identified, evaluated, summarized. Results Thirty reports met inclusion criteria. The majority prospective (73.33%, n = 22) nature. most utilized 15 O-labeled radio water (H 2 O, 14) 18 F-fluorodeoxyglucose ( F-FDG, 8). Other used at least one study 14(R,S)-(18)F-fluoro-6-thia-heptadecanoic acid F-FTHA), F-Sodium Fluoride F-NaF), 11 C-acetate, 68-Gallium 68 Ga), 13 N-ammonia N-NH 3 ), Rubidium-82 82 Rb), radiolabeled cationic ferritin (RadioCF), C‐para-aminobenzoic C-PABA), Gallium-68 pentixafor Ga-Pentixafor), 2-deoxy-2-F-fluoro- d -sorbitol (F-FDS) 55 Co-ethylene diamine tetra acetic Co-EDTA). Conclusion provides an effective modality evaluating range functions including glucose fatty uptake, oxygen consumption perfusion. Multiple positron emitting racers can be clinical settings. thus holds potential improve diagnosis disorders, disease progression treatment